Description

1-Azabicyclo[2.2.1]Heptane-3-Carbonyl Chloride, Endo- (9Ci) is a high-value, specialized bicyclic building block featuring a reactive acid chloride functional group. This compound matters as a critical chiral intermediate for the synthesis of complex pharmaceutical molecules, enabling the construction of constrained, three-dimensional molecular architectures. It is primarily needed by research and development chemists and process development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of central nervous system (CNS) active drugs, enzyme inhibitors, and other bioactive molecules.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides that require specific stereochemistry for efficacy.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetic Research: Employed to introduce rigid, bicyclic scaffolds into peptide backbones to enhance metabolic stability and receptor selectivity.
• Chemical Biology Probes: Useful for synthesizing tool compounds and molecular probes to study biological pathways and protein function.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific projects requiring advanced bicyclic intermediates.

Basic Information

Product Name	1-Azabicyclo[2.2.1]Heptane-3-Carbonyl Chloride, Endo- (9Ci)
CAS No.	730925-03-8
Molecular Formula	C7H10ClNO
Molecular Weight	159.61 g/mol
Synonyms	Endo-1-Azabicyclo[2.2.1]heptane-3-carbonyl chloride; (1R,4S)-1-Azabicyclo[2.2.1]heptane-3-carbonyl chloride; 3-Carbamoyl-1-azabicyclo[2.2.1]heptane hydrochloride (related); Bicyclo[2.2.1]heptane-3-carbonyl chloride, 1-aza-, endo-; 730925-03-8; 1-Azabicyclo[2.2.1]heptane-3-carbonyl chloride, endo- isomer; endo-3-(Chlorocarbonyl)-1-azabicyclo[2.2.1]heptane
EINECS	Contact for details

Quality Control

Our 1-Azabicyclo[2.2.1]Heptane-3-Carbonyl Chloride, Endo- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid or crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (Endo- isomer)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.