Description

5-Fluoro-4-Thio-1-(2'', 3'', 5''-Tri-o-Benzoyl-β-L-Ribofuranosyl)Uracil is a sophisticated nucleoside analogue derivative, serving as a critical building block in advanced pharmaceutical research and development. Its primary value lies in its role as a key synthetic intermediate for novel antiviral and anticancer therapeutics, particularly in the development of modified nucleoside prodrugs. This high-purity compound is essential for research institutions, pharmaceutical companies, and CROs engaged in the synthesis of next-generation antiviral agents targeting RNA viruses and exploring novel mechanisms in oncology.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Antiviral Research: Used in the development of prodrugs and active pharmaceutical ingredients (APIs) targeting viruses such as hepatitis C virus (HCV), influenza, and other RNA viruses.
• Oncology Research: Serves as a building block for creating nucleoside analogues that inhibit cancer cell proliferation by interfering with DNA/RNA synthesis.
• Biochemical Tool: Employed in enzymatic studies and as a substrate analog to investigate the mechanisms of viral polymerases and cellular enzymes.
• Process Chemistry & Scale-Up: Used in route scouting, optimization, and GMP-scale manufacturing of clinical trial materials.
• Academic Research: A valuable compound for universities and research institutes studying nucleic acid chemistry, medicinal chemistry, and drug design.

Basic Information

Item	Detail
Product Name	5-Fluoro-4-Thio-1-(2'', 3'', 5''-Tri-o-Benzoyl-β-L-Ribofuranosyl)Uracil
CAS No.	725257-84-1
Molecular Formula	C30H23FN2O8S
Molecular Weight	590.58 g/mol
Synonyms	4-Thio-5-fluoro-1-[(2S,3S,4R,5R)-3,4-bis(benzoyloxy)-5-(benzoyloxymethyl)oxolan-2-yl]pyrimidine-2-one; 5-Fluoro-4-thio-1-((2S,3S,4R,5R)-3,4-bis(benzoyloxy)-5-((benzoyloxy)methyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one; 1-(2,3,5-Tri-O-benzoyl-β-L-ribofuranosyl)-5-fluoro-4-thiouracil; 5-Fluoro-4-thio-1-(2,3,5-tri-O-benzoyl-β-L-ribofuranosyl)uracil; 4-Thio-5-fluoro-1-(2,3,5-tri-O-benzoyl-β-L-ribofuranosyl)uracil; β-L-TriBz-5F-4SU; L-5F-4SU TriBz Ester
EINECS	Contact for details

Quality Control

Our 5-Fluoro-4-Thio-1-(2'', 3'', 5''-Tri-o-Benzoyl-β-L-Ribofuranosyl)Uracil is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes to ensure the material meets the stringent requirements for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under inert atmosphere when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.