Description

1H-Pyrazole-3-Acetamide, 5-[[7-[3-[Ethyl(2-Hydroxyethyl)Amino]Propoxy]-4-Quinazolinyl]Amino]-n-(3-Fluorophenyl)- is a sophisticated heterocyclic organic compound designed for advanced research and development applications. This molecule is of significant interest due to its complex structure, which combines pyrazole and quinazoline pharmacophores, suggesting potential as a key intermediate or active component in pharmaceutical discovery. It is primarily targeted at R&D chemists and process development scientists working in the fields of oncology, kinase inhibition, and novel therapeutic agent synthesis. The compound, with CAS number 722544-51-6, represents a high-value building block for cutting-edge medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Serves as a critical synthetic precursor in the development of targeted kinase inhibitors and other small-molecule therapeutics.
• Oncology Research: Used in biological screening and structure-activity relationship (SAR) studies for potential anti-cancer agents, particularly those targeting specific signaling pathways.
• Medicinal Chemistry R&D: Employed as a versatile scaffold for the design and synthesis of novel chemical entities with optimized pharmacological properties.
• Biochemical Tool Compound: Acts as a probe in enzymatic assays and cellular studies to investigate protein function and disease mechanisms.
• Process Chemistry & Scale-up: Utilized in route scouting and optimization for the efficient, scalable production of advanced drug candidates.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and development pipelines for global biopharma clients.

Basic Information

Product Name	1H-Pyrazole-3-Acetamide, 5-[[7-[3-[Ethyl(2-Hydroxyethyl)Amino]Propoxy]-4-Quinazolinyl]Amino]-n-(3-Fluorophenyl)-
CAS No.	722544-51-6
Molecular Formula	C27H31FN6O3
Molecular Weight	506.57 g/mol
Synonyms	5-[[7-[3-[Ethyl(2-Hydroxyethyl)Amino]Propoxy]-4-Quinazolinyl]Amino]-N-(3-Fluorophenyl)-1H-Pyrazole-3-Acetamide; N-(3-Fluorophenyl)-5-({7-[3-(ethyl(2-hydroxyethyl)amino)propoxy]quinazolin-4-yl}amino)-1H-pyrazole-3-carboxamide; 722544-51-6; UNII-7V2Q2J8Q5K; 7V2Q2J8Q5K; CHEMBL3186475; BDBM50389378; AKOS009158974
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and reliability for your research. Each lot undergoes comprehensive analytical characterization using techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes. We support development under cGMP guidelines where required, ensuring suitability for use in pre-clinical and early-phase clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.