Description

Azd1152 CAS NO 722543-31-9 is a potent and selective small-molecule inhibitor of Aurora B kinase, a key regulator of cell division. This compound is of significant value for research into cell cycle control, mitotic progression, and the development of targeted cancer therapeutics. It is primarily needed by pharmaceutical R&D departments, academic research institutions, and biotechnology companies focused on oncology and molecular biology.

Application

• Biochemical Research: Used as a critical tool compound to study the specific functions and inhibition mechanisms of Aurora B kinase in cellular pathways.
• Oncology Drug Discovery: Serves as a lead compound or reference standard in the development of novel anti-cancer agents targeting mitotic kinases.
• Cell Biology Studies: Applied in vitro to investigate chromosome alignment, cytokinesis, and the consequences of mitotic checkpoint failure.
• Preclinical Evaluation: Utilized in animal models to assess the pharmacokinetics, efficacy, and safety profile of Aurora kinase inhibition.
• High-Throughput Screening (HTS): Acts as a control or validation compound in screening assays designed to identify new kinase inhibitors.

Basic Information

Product Name	Azd1152
CAS No.	722543-31-9
Molecular Formula	C₂₆H₃₃FN₈O₃
Molecular Weight	524.59 g/mol
Synonyms	AZD1152; AZD-1152; Barasertib; Barasertib (AZD1152); 5-[2-(Ethyl{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}amino)pyrimidin-4-yl]-4-fluoro-2-methylbenzamide; (S)-5-(2-(Ethyl(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)-4-fluoro-2-methylbenzamide; Aurora B Kinase Inhibitor AZD1152
EINECS	Contact for details

Quality Control

Our Azd1152 is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. For long-term storage, keep desiccated under an inert atmosphere. Allow the product to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.