Description

8-Bromo-N2-(Dimethylaminomethylidene)-2'-Deoxyguanosine is a high-purity, modified nucleoside derivative of significant value in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate and building block for the creation of novel oligonucleotides and nucleotide analogs. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of antiviral agents, anticancer therapeutics, and molecular probes for genetic studies.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for introducing modified guanine bases into synthetic DNA strands.
• Antiviral Drug Development: Used in the research and synthesis of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral compounds.
• Anticancer Research: Serves as a building block for creating nucleotide analogs that target DNA replication in cancer cells.
• Molecular Biology Probes: Enables the synthesis of labeled nucleotides for use in sequencing, PCR, and hybridization assays.
• Bioconjugation: The reactive bromo group allows for site-specific conjugation with other molecules for diagnostic or therapeutic applications.
• Medicinal Chemistry: A versatile intermediate for structure-activity relationship (SAR) studies in drug discovery programs.

Basic Information

Product Name	8-Bromo-N2-(Dimethylaminomethylidene)-2'-Deoxyguanosine
CAS No.	717876-75-0
Molecular Formula	C13H16BrN5O4
Molecular Weight	386.20 g/mol
Synonyms	8-Bromo-2'-deoxy-N2-(dimethylaminomethylene)guanosine; 8-Br-dG(N2-DMF) Amidite Precursor; 8-Bromo-N2-(dimethylaminomethylidene)-2'-deoxyguanosine; 8-Bromo-2'-deoxyguanosine N2-(dimethylaminomethylene) derivative; 8-Bromo-N2-DMF-dG; 8-Br-dG(DMF) (abbrev.); 2'-Deoxy-8-bromoguanosine N2-(dimethylaminomethylene) acetal
EINECS	Contact for details

Quality Control

Our 8-Bromo-N2-(Dimethylaminomethylidene)-2'-Deoxyguanosine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.