Description

1H-Pyrazole-3-Carbonyl Chloride is a versatile and reactive organic building block, specifically an acid chloride derivative of a pyrazole carboxylic acid. Its primary value lies in its role as a key intermediate for the synthesis of more complex molecules, particularly in pharmaceutical and agrochemical research. This compound is essential for chemists and manufacturers developing active pharmaceutical ingredients (APIs), crop protection agents, and advanced functional materials who require high-purity, reliable synthetic intermediates.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly those containing the pyrazole heterocycle, which is prevalent in molecules with anti-inflammatory, analgesic, and anticancer activities.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the pyrazole moiety contributes to biological activity and selectivity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in coordination chemistry and homogeneous catalysis.
• Material Science Research: Employed in the synthesis of organic polymers and functional materials with specific electronic or optical properties.
• Custom Synthesis and Contract Manufacturing: A fundamental reagent for fine chemical and custom synthesis houses serving the life sciences industry.
• Bioconjugation and Probe Synthesis: Useful for attaching pyrazole-based tags or labels to biomolecules for diagnostic or research purposes.

Basic Information

Product Name	1H-Pyrazole-3-Carbonyl Chloride
CAS No.	717871-84-6
Molecular Formula	C4H3ClN2O
Molecular Weight	130.53 g/mol
Synonyms	1H-Pyrazole-3-carbonyl chloride; 3-Pyrazolecarbonyl chloride; Pyrazole-3-carbonyl chloride; 1H-Pyrazole-3-carboxylic acid chloride; 3-Carboxypyrazole chloride; 717871-84-6; Pyrazolyl-3-carbonyl chloride
EINECS	Contact for details

Quality Control

Our 1H-Pyrazole-3-Carbonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality management system supports compliance with cGMP and ISO standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent derivative, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.