Description

2-Pyridinecarbonyl Chloride, 5-Fluoro- (9Ci) is a high-purity, reactive heterocyclic building block essential for advanced organic synthesis. This compound is valued for its role as a key acylating agent, enabling the efficient introduction of the 5-fluoropyridine-2-carbonyl moiety into target molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that incorporate fluorinated pyridine structures.
• Chemical Biology & Proteomics: Serves as a reagent for modifying peptides, proteins, or other biomolecules to create probes, inhibitors, or affinity labels.
• Material Science Research: Employed in the synthesis of functionalized ligands for metal-organic frameworks (MOFs) or catalysts.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-Pyridinecarbonyl Chloride, 5-Fluoro- (9Ci)
CAS No.	717871-83-5
Molecular Formula	C6H3ClFNO
Molecular Weight	159.55 g/mol
Synonyms	5-Fluoropyridine-2-carbonyl chloride; 5-Fluoropicolinoyl chloride; 2-Carbonyl chloride-5-fluoropyridine; 5-Fluoro-2-pyridinecarboxylic acid chloride; 5-Fluoropicolinic acid chloride; 5-Fluoro-2-picolinoyl chloride
EINECS	Contact for details

Quality Control

Our 2-Pyridinecarbonyl Chloride, 5-Fluoro- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of GMP environments for non-GMP starting materials and supports global regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and moisture-sensitive nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.