Description

Ac480 (BMS-599626) is a potent and selective small molecule inhibitor of the human epidermal growth factor receptor (HER) family of tyrosine kinases. This compound is a critical research tool for investigating signaling pathways involved in cell proliferation and survival, with significant implications for oncology research and drug discovery. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) focused on developing targeted cancer therapies.

Application

• Biochemical Research: Used as a selective inhibitor to study the role of HER family kinases (EGFR, HER2, HER4) in cellular signaling cascades.
• Oncology Drug Discovery: Serves as a key pharmacological tool and reference standard in high-throughput screening and lead optimization programs for anticancer agents.
• Mechanistic Studies: Enables investigation into tumor cell proliferation, survival, and resistance mechanisms in various cancer cell lines.
• Preclinical Development: Utilized in in vitro and in vivo models to evaluate the efficacy and pharmacodynamics of HER-targeted therapeutic strategies.

Basic Information

Product Name	Ac480 (BMS-599626)
CAS No.	714971-09-2
Molecular Formula	C₂₆H₂₅ClFN₅O₃
Molecular Weight	509.96 g/mol
Synonyms	BMS-599626; AC-480; (3R,4R)-4-Amino-1-((4-((3-methoxyphenyl)amino)pyrrolo[2,1-f][1,2,4]triazin-5-yl)methyl)piperidin-3-ol; Pan-HER Inhibitor; HER Kinase Inhibitor AC480; EGFR/HER2 Inhibitor
EINECS	Contact for details

Quality Control

Our Ac480 (BMS-599626) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our stringent internal specifications for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.