Description

3-Bromo-4-Fluorophenyl Isothiocyanate is a versatile aromatic isothiocyanate derivative, serving as a critical building block in advanced organic synthesis. Its reactive isothiocyanate group enables efficient derivatization, making it invaluable for constructing complex molecular architectures. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, particularly for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, especially for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, leveraging the bioactivity of the fluorinated phenyl ring.
• Ligand and Chelator Development: Serves as a starting material for creating specialized ligands used in catalysis and metal complexation studies.
• Functional Material Precursor: Employed in the synthesis of monomers and polymers with specific optical or electronic properties for advanced materials.
• Chemical Biology Probe Synthesis: Useful for labeling and modifying biomolecules (proteins, peptides) due to the reactivity of the isothiocyanate group with amines.
• Cross-coupling Reactions: The bromo substituent makes it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira).

Basic Information

Item	Detail
Product Name	3-Bromo-4-Fluorophenyl Isothiocyanate
CAS No.	710351-24-9
Molecular Formula	C7H3BrFNS
Molecular Weight	232.07 g/mol
Synonyms	1-Bromo-2-fluoro-4-isothiocyanatobenzene; 4-Fluoro-3-bromophenyl isothiocyanate; 3-Bromo-4-fluorobenzene isothiocyanate; (3-Bromo-4-fluorophenyl) isothiocyanate; 2-Fluoro-5-isothiocyanato-1-bromobenzene; Isothiocyanic acid, 3-bromo-4-fluorophenyl ester; SC-1-Bromo-2-fluoro-4-phenyl
EINECS	Contact for details

Quality Control

Our 3-Bromo-4-Fluorophenyl Isothiocyanate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.