Description

Cyclopropanecarbonyl Chloride, 2,2-Dichloro-1-Methyl-, (1S)- (9Ci) is a high-purity, chiral organochlorine compound with the CAS number 701223-12-3. It serves as a critical chiral building block and acylating agent in advanced organic synthesis, enabling the introduction of the sterically hindered and stereochemically defined cyclopropane moiety. This material is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly where stereochemistry is a key determinant of biological activity.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and antiviral drug discovery.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where the cyclopropane structure confers specific biological activity and stability.
• Asymmetric Synthesis: Employed as a chiral acylating agent or electrophile in stereoselective reactions to construct complex molecular architectures.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organocatalysts used in homogeneous catalysis.
• Material Science Research: Building block for novel polymers or specialty chemicals with unique properties derived from the strained cyclopropane ring.
• Process Chemistry & Scale-Up: Used in route development and optimization for the commercial manufacturing of fine chemicals.

Basic Information

Item	Detail
Product Name	Cyclopropanecarbonyl Chloride, 2,2-Dichloro-1-Methyl-, (1S)- (9Ci)
CAS No.	701223-12-3
Molecular Formula	C5H5Cl3O
Molecular Weight	187.45 g/mol
Synonyms	(1S)-2,2-Dichloro-1-methylcyclopropanecarbonyl chloride; (-)-2,2-Dichloro-1-methylcyclopropanecarbonyl chloride; (S)-2,2-Dichloro-1-methylcyclopropanecarbonyl chloride; 1-Methyl-2,2-dichlorocyclopropanecarboxylic acid chloride, (1S)-; (1S)-1-Methyl-2,2-dichlorocyclopropanecarboxylic acid chloride; (S)-1-Methyl-2,2-dichlorocyclopropanecarboxylic acid chloride
EINECS	Contact for details

Quality Control

Our Cyclopropanecarbonyl Chloride, 2,2-Dichloro-1-Methyl-, (1S)- (9Ci) is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and highly volatile; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (Karl Fischer)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.