Description

2,4-Dibromo-17-Ethynyl(6,7)Estradiol is a synthetic, halogenated derivative of estradiol, a key steroid hormone. This compound is of significant interest in advanced pharmaceutical research and development, particularly for creating novel therapeutic agents and molecular probes. It serves as a critical synthetic intermediate for medicinal chemists and researchers in the life sciences sector. The compound's modified structure provides unique reactivity and binding properties essential for targeted drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel steroidal drugs and hormone receptor modulators.
• Biochemical Research: Used as a molecular probe to study estrogen receptor (ER) binding affinity, specificity, and signaling pathways.
• Medicinal Chemistry: Serves as a precursor for the development of potential anti-cancer agents, particularly for hormone-dependent cancers.
• Academic & Institutional R&D: Employed in university and institutional laboratories for fundamental research in endocrinology and steroid chemistry.
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control in related API manufacturing.

Basic Information

Product Name	2,4-Dibromo-17-Ethynyl(6,7)Estradiol
CAS No.	79769-52-1
Molecular Formula	C20H22Br2O2
Molecular Weight	454.20 g/mol
Synonyms	2,4-Dibromo-17α-ethynylestra-1,3,5(10)-triene-3,17β-diol; 17α-Ethynyl-2,4-dibromoestra-1,3,5(10)-triene-3,17β-diol; 2,4-Dibromo-17α-ethynylestradiol; 2,4-Dibromoethynylestradiol; NSC 124095; Estradiol, 2,4-dibromo-17-ethynyl-; 17-Ethynyl-2,4-dibromoestra-1,3,5(10)-triene-3,17-diol
EINECS	Contact for details

Quality Control

Our 2,4-Dibromo-17-Ethynyl(6,7)Estradiol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We are committed to providing materials that support reproducible and reliable scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light). For long-term storage, consider storing under an inert atmosphere at lower temperatures (e.g., -20°C) to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.