Description

4-(n-2-Chloroethyl-n-Methyl)Aminobenzyl-5'-Phosphoamide Heptauridylate is a specialized, high-purity nucleotide analog with the CAS number 79486-46-7. This compound is a critical intermediate in advanced pharmaceutical research, particularly in the development of targeted therapeutic agents and oligonucleotide-based drugs. It is essential for research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on oncology, antiviral therapies, and genetic medicine.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel nucleotide-based active pharmaceutical ingredients (APIs).
• Oligonucleotide Synthesis: Used in the research and development of antisense oligonucleotides, siRNA, and other gene-silencing therapeutics.
• Bioconjugation Research: Serves as a precursor for creating targeted drug conjugates due to its reactive chloroethyl and phosphoamide groups.
• Biochemical Research: A valuable tool for studying enzyme mechanisms, nucleic acid interactions, and cellular signaling pathways in academic and industrial labs.
• Preclinical Development: Employed in the early-stage development and optimization of candidate drugs for various disease targets.

Basic Information

Product Name	4-(n-2-Chloroethyl-n-Methyl)Aminobenzyl-5'-Phosphoamide Heptauridylate
CAS No.	79486-46-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	4-[(2-Chloroethyl)(methyl)amino]benzyl 5'-phosphoamide heptauridylate; Heptauridylate phosphoramidate derivative; Nucleotide analog 79486-46-7; 4-(N-2-Chloroethyl-N-methylamino)benzyl P-heptauridylate; 5'-O-Phosphoramidoyluridine heptamer derivative; Targeted nucleotide prodrug intermediate; Antisense oligonucleotide precursor
EINECS	Contact for details

Quality Control

Our 4-(n-2-Chloroethyl-n-Methyl)Aminobenzyl-5'-Phosphoamide Heptauridylate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory and preclinical requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions or a dry inert atmosphere to maintain stability. For long-term storage, consider desiccants or storage under argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.