Description

n-(N'-(2-(4'-Methylmorpholinio)Ethyl)-N''-Cyclohexylguanyl)Amphotericin B Methyl Ester is a chemically modified derivative of the potent polyene macrolide antibiotic, Amphotericin B, designed to enhance solubility and potentially alter its pharmacological profile. This semi-synthetic compound is critical for advanced pharmaceutical research, particularly in developing novel antifungal agents and targeted drug delivery systems. It serves as a key intermediate for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on overcoming the limitations of native amphotericin B, such as toxicity and formulation challenges.

Application

• Pharmaceutical Intermediate: Primary use as a building block in the synthesis of next-generation antifungal drugs with improved therapeutic indices.
• Antifungal Research: A vital reference standard and active compound in preclinical studies investigating mechanisms of action against resistant fungal strains.
• Drug Delivery System Development: Utilized in creating liposomal, nanoparticle, or conjugate formulations to enhance bioavailability and reduce nephrotoxicity.
• Structure-Activity Relationship (SAR) Studies: Essential for medicinal chemists to understand how chemical modifications affect the biological activity of polyene antibiotics.
• Bioconjugation & Prodrug Synthesis: Serves as a substrate for developing targeted therapies where the antibiotic is linked to antibodies or other targeting moieties.

Basic Information

Product Name	n-(N'-(2-(4'-Methylmorpholinio)Ethyl)-N''-Cyclohexylguanyl)Amphotericin B Methyl Ester
CAS No.	79451-27-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Amphotericin B Methyl Ester, N-(N'-(2-(4'-Methylmorpholinio)ethyl)-N''-cyclohexylguanyl) Derivative; 79451-27-7; Amphotericin B ME derivative; Cyclohexylguanyl Amphotericin B Methyl Ester; 4'-Methylmorpholinoethyl Cyclohexylguanyl Amphotericin B Methyl Ester; Modified Amphotericin B Ester; N-Cyclohexyl-N'-(2-(4-methylmorpholino)ethyl)guanidino Amphotericin B Methyl Ester
EINECS	Contact for details

Quality Control

Our n-(N'-(2-(4'-Methylmorpholinio)Ethyl)-N''-Cyclohexylguanyl)Amphotericin B Methyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical results is provided with every shipment to guarantee traceability and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to Brown Powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to Reference Spectrum
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.