Description

Cilofungin is a potent antifungal echinocandin B analog, specifically developed as a noncompetitive inhibitor of the fungal cell wall synthesis enzyme (1,3)-β-D-glucan synthase. This targeted mechanism of action makes it a valuable compound for research into novel antifungal agents and resistance mechanisms. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies focused on developing new therapeutic strategies against invasive fungal infections.

Application

• Antifungal Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) in the discovery and development of new echinocandin-class antifungal drugs.
• Biochemical Studies: Used as a specific enzymatic inhibitor to study the (1,3)-β-D-glucan synthase pathway and fungal cell wall biosynthesis in laboratory settings.
• Microbiology & Pharmacology: Employed in in vitro and in vivo studies to evaluate antifungal efficacy, spectrum of activity, and pharmacodynamic properties.
• Quality Control & Analytical Testing: Functions as a high-purity analytical standard for HPLC, LC-MS, or other chromatographic methods in pharmaceutical quality control laboratories.
• Mechanism of Action Research: Critical for investigating fungal resistance patterns and the detailed molecular interactions of echinocandin drugs with their target.

Basic Information

Product Name	Cilofungin
CAS No.	79404-91-4
Molecular Formula	C52H81N7O15
Molecular Weight	1044.25 g/mol
Synonyms	LY 121019; Echinocandin B, 4-[4-(4-hydroxyphenyl)-1-piperazinyl]-3-(4-hydroxyphenyl)-, (4R,5R)-; (4R,5R)-4-[4-(4-Hydroxyphenyl)-1-piperazinyl]-3-(4-hydroxyphenyl)-echinocandin B; CL 121,019; Antibiotic LY 121019
EINECS	Contact for details

Quality Control

Our Cilofungin is manufactured and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, HPLC), purity assay (HPLC), and control of related substances and residual solvents, to ensure it meets high-grade research standards. A detailed Certificate of Analysis (COA) with batch-specific data is provided with every shipment to guarantee traceability and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.