Description

Tapinarof is a novel, first-in-class therapeutic aryl hydrocarbon receptor (AhR) modulating agent. This compound is significant for its non-steroidal, topical mechanism of action, offering a new treatment paradigm for inflammatory skin conditions. It is primarily required by pharmaceutical R&D teams and manufacturers developing advanced dermatological treatments for global markets.

Application

• Primary Pharmaceutical Ingredient: Core active pharmaceutical ingredient (API) in topical formulations for the treatment of plaque psoriasis.
• Dermatological R&D: Key compound in research and development of novel therapies for atopic dermatitis and other chronic inflammatory skin diseases.
• Clinical Trial Material: Sourced as a high-purity reference standard and bulk API for Phase I-III clinical studies.
• Mechanistic Studies: Used in biochemical and pharmacological research to study AhR pathway modulation and its anti-inflammatory effects.
• Formulation Development: Serves as the active component in the development of creams, ointments, and other topical delivery systems.
• Comparator & Biosimilar Development: Used as a reference compound in the development of generic or biosimilar versions of approved tapinarof-based drugs.

Basic Information

Product Name	Tapinarof
CAS No.	79338-84-4
Molecular Formula	C₁₇H₁₄O₃
Molecular Weight	266.29 g/mol
Synonyms	GSK2894512; Benvitimod; WBI-1001; 1-(2,4-Dihydroxyphenyl)-3-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one; 3-(2,4-Dihydroxyphenyl)-1-(2-hydroxy-4-methoxyphenyl)prop-2-en-1-one; 1,3-Bis(2,4-dihydroxyphenyl)-2-propen-1-one (related isomer); AhR Modulator GSK2894512
EINECS	Contact for details

Quality Control

Our Tapinarof is manufactured under strict quality management systems. Each batch is tested to meet high-purity pharmaceutical standards, with comprehensive analytical methods including HPLC for assay and related substances. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to ensure traceability and compliance with cGMP guidelines for API manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment. For long-term storage, consider desiccants or inert atmosphere packing.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.