Description

D-Alanine, Trimethylsilyl Ester (9Ci) is a protected derivative of the non-natural D-enantiomer of the amino acid alanine, where the carboxylic acid group is masked as a trimethylsilyl ester. This functionalization is critical for enhancing solubility in organic solvents and preventing unwanted side reactions during complex synthetic sequences, particularly in peptide synthesis. It serves as a valuable chiral building block and synthetic intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, enantiomerically pure compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs), especially for antibiotics, enzyme inhibitors, and peptide-based therapeutics.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate D-alanine residues, which are crucial for creating peptides with enhanced metabolic stability and specific biological activity.
• Agrochemical Research: Serves as a precursor in the development of chiral herbicides, fungicides, and plant growth regulators where the D-configuration imparts specific biological activity.
• Chemical Biology & Proteomics: Employed in the synthesis of isotopically labeled peptides, activity-based probes, and other tools for studying enzyme mechanisms and protein interactions.
• Material Science: Acts as a monomer or modifying agent for creating chiral polymers and functionalized surfaces with specific stereochemical properties.
• Asymmetric Synthesis Catalyst Ligand: Can be utilized in the preparation of chiral ligands or organocatalysts for asymmetric transformations.

Basic Information

Product Name	D-Alanine, Trimethylsilyl Ester (9Ci)
CAS No.	79338-42-4
Molecular Formula	C6H15NO2Si
Molecular Weight	161.28 g/mol
Synonyms	D-Alanine trimethylsilyl ester; (R)-2-((Trimethylsilyl)oxy)propanenitrile; Alanine, D-, trimethylsilyl ester; D-Alanine TMS ester; (R)-2-Cyano-1-trimethylsilyloxyethane; Trimethylsilyl D-alaninate; D-2-((Trimethylsilyl)oxy)propionitrile
EINECS	Contact for details

Quality Control

Our D-Alanine, Trimethylsilyl Ester (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and identity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.