Description

2',3,-o-Isopropylidene-5'-Deoxy-6(R),5'-Cyclo-5,6-Dihydrouridine is a sophisticated nucleoside analog derivative, serving as a critical advanced intermediate in modern pharmaceutical and biochemical research. Its unique fused bicyclic structure makes it an invaluable building block for the synthesis of novel antiviral and anticancer agents, particularly in the development of modified nucleoside therapeutics. This high-purity compound is essential for research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on nucleoside chemistry and prodrug development.

Application

• Pharmaceutical Intermediate: Key synthetic precursor for the development of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used in studies investigating nucleoside metabolism, enzyme inhibition, and structure-activity relationships (SAR).
• Prodrug Synthesis: Serves as a protected intermediate in the design and synthesis of nucleoside prodrugs to enhance bioavailability.
• Antiviral Agent Development: Building block for research into treatments for viral infections such as hepatitis and herpes viruses.
• Labeled Compound Synthesis: Intermediate for the preparation of isotopically labeled (e.g., C13, N15) nucleosides for metabolic tracing studies.
• Academic & Industrial R&D: Fundamental material for organic synthesis and medicinal chemistry projects in both university and corporate settings.

Basic Information

Product Name	2',3,-o-Isopropylidene-5'-Deoxy-6(R),5'-Cyclo-5,6-Dihydrouridine
CAS No.	79298-16-1
Molecular Formula	C12H16N2O5
Molecular Weight	268.27 g/mol
Synonyms	5'-Deoxy-5,6-dihydro-2',3'-O-isopropylideneuridine; 6(R),5'-Cyclo-5,6-dihydro-2',3'-O-isopropylideneuridine; 2',3'-O-Isopropylidene-5'-deoxy-6(R),5'-cyclo-5,6-dihydrouridine; 5,6-Dihydro-2',3'-O-isopropylidene-5'-deoxyuridine; 6(R),5'-Cyclo-5,6-dihydro-2',3'-O-(1-methylethylidene)uridine; Dihydrouridine isopropylidene derivative; Protected dihydrouridine analog
EINECS	Contact for details

Quality Control

Our 2',3,-o-Isopropylidene-5'-Deoxy-6(R),5'-Cyclo-5,6-Dihydrouridine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical intermediate supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.