Description

n-Benzoyl-3',5'-o-[1,1,3,3-Tetrakis(1-Methylethyl)-1,3-Disiloxanediyl]Adenosine CAS NO 79154-57-7 is a sophisticated, protected nucleoside derivative, specifically engineered as a critical building block in oligonucleotide synthesis. Its primary value lies in providing a highly reactive and selectively protected adenosine moiety, enabling the precise construction of DNA and RNA sequences. This compound is essential for researchers and manufacturers in the fields of pharmaceutical development, molecular diagnostics, and biotechnology, where reliable, high-purity synthetic intermediates are paramount for success.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): A key phosphoramidite precursor for the automated synthesis of DNA and RNA strands.
• Antisense Oligonucleotide (ASO) & siRNA Production: Used in the manufacture of therapeutic oligonucleotides for targeted gene silencing and regulation.
• Research & Development of Nucleic Acid Therapeutics: Serves as a fundamental building block in academic and industrial labs developing novel genetic medicines.
• Diagnostic Probe Synthesis: Employed in creating labeled probes for techniques like FISH (Fluorescence In Situ Hybridization) and PCR.
• Synthesis of Modified Nucleosides: Acts as a protected intermediate for further chemical modifications to create nucleoside analogs with enhanced properties.
• Process Development & Scale-Up: Supports the transition from laboratory-scale research to commercial manufacturing of oligonucleotide-based products.

Basic Information

Product Name	n-Benzoyl-3',5'-o-[1,1,3,3-Tetrakis(1-Methylethyl)-1,3-Disiloxanediyl]Adenosine
CAS No.	79154-57-7
Molecular Formula	C31H47N5O6Si2
Molecular Weight	641.91 g/mol
Synonyms	N6-Benzoyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)adenosine; 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-N6-benzoyladenosine; N6-Bz-3',5'-O-TIPDS-Adenosine; TIPDS-protected N6-Benzoyladenosine; Adenosine, N-benzoyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-; N-Bz-Adenosine-3',5'-TIPDS; 79154-57-7; N6-Benzoyl-3',5'-O-(tetraisopropyldisiloxan-1,3-diyl)adenosine
EINECS	Contact for details

Quality Control

Every batch of our n-Benzoyl-3',5'-o-[1,1,3,3-Tetrakis(1-Methylethyl)-1,3-Disiloxanediyl]Adenosine is produced and tested under strict quality management systems to ensure it meets the exacting standards required for oligonucleotide synthesis. We employ advanced analytical techniques including HPLC, NMR, and mass spectrometry for identity confirmation and purity verification. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.