Description

2(1H)-Pyrimidinone, 4-Amino-1-(2-Azido-2-Deoxy-5-o-(Hydroxy((Hydroxy(P Hosphonooxy)Phosphinyl)Oxy)Phosphinyl)-β-D-Arabinofuranosyl)- is a sophisticated nucleoside analogue with a complex triphosphate-like moiety, making it a critical building block for advanced biochemical research and pharmaceutical development. Its primary value lies in its role as a modified nucleotide precursor, enabling the study and manipulation of nucleic acid metabolism and enzyme function. This high-purity compound is essential for researchers and manufacturers in antiviral drug discovery, molecular biology, and nucleotide-based prodrug synthesis, where precise chemical structure is paramount for biological activity.

Application

• Antiviral Drug Discovery & Development: Serves as a key intermediate or active pharmaceutical ingredient (API) precursor for novel nucleoside analogue therapeutics targeting viral polymerases.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly for research involving DNA/RNA polymerases, kinases, and other nucleotide-processing enzymes.
• Prodrug Synthesis: Acts as a core scaffold for the development of nucleotide prodrugs (e.g., ProTide technology) designed to improve cellular uptake and metabolic activation.
• Molecular Biology Tools: Incorporated into oligonucleotides for probing nucleic acid structure, function, and for developing diagnostic assays.
• Medicinal Chemistry: Provides a versatile template for structure-activity relationship (SAR) studies to optimize potency and selectivity against biological targets.
• High-Throughput Screening (HTS): Utilized in target-based screening libraries to identify new modulators of nucleotide-dependent pathways.

Basic Information

Item	Details
Product Name	2(1H)-Pyrimidinone, 4-Amino-1-(2-Azido-2-Deoxy-5-o-(Hydroxy((Hydroxy(P Hosphonooxy)Phosphinyl)Oxy)Phosphinyl)-β-D-Arabinofuranosyl)-
CAS No.	79065-89-7
Molecular Formula	C9H15N6O13P3
Molecular Weight	556.13 g/mol
Synonyms	4-Amino-1-((2R,3S,4R,5R)-5-((((((Hydroxy(phosphonooxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)methyl)-3-azido-4-hydroxytetrahydrofuran-2-yl)pyrimidin-2(1H)-one; 1-(2-Azido-2-deoxy-5-O-({hydroxy[(hydroxy{[(hydroxy)phosphonooxy]phosphoryl})oxy]phosphoryl}oxy)methyl]-β-D-arabinofuranosyl)-4-aminopyrimidin-2(1H)-one; Azido Nucleoside Triphosphate Analogue; β-D-Arabinofuranosyl Nucleotide Derivative; Modified Nucleoside 5'-Triphosphate; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of this high-value nucleotide analogue is produced and analyzed under strict quality control protocols to ensure identity, purity, and consistency for sensitive research and development applications. We adhere to cGMP principles where applicable for pharmaceutical-grade material. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results from advanced analytical techniques including HPLC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, temperature-controlled environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or moisture will compromise stability and purity. For long-term storage, consider desiccation and storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 3.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.