Description

Dl-2-Amino-7-Phosphonoheptanoic Acid CAS NO 78966-69-5 is a synthetic, phosphonic acid-containing amino acid analog that serves as a potent and selective antagonist of the N-methyl-D-aspartate (NMDA) receptor. This compound is a critical research tool for studying excitatory neurotransmission, neuronal plasticity, and the pathophysiology of neurological disorders. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and specialty chemical manufacturers focused on neuroscience and neuropharmacology.

Application

• Neuroscience Research: A key pharmacological agent for investigating the role of NMDA receptors in synaptic transmission, long-term potentiation (LTP), and excitotoxicity.
• Neuropharmacology Studies: Used in preclinical models to study potential therapeutic interventions for stroke, traumatic brain injury, epilepsy, and neurodegenerative diseases like Alzheimer's.
• Biochemical Assay Development: Serves as a standard or reference compound in high-throughput screening (HTS) assays designed to discover novel NMDA receptor modulators.
• Chemical Synthesis Intermediate: Acts as a specialized building block for the synthesis of more complex neuroactive compounds or labeled analogs for tracer studies.
• Academic & Institutional Research: Essential for university and hospital laboratories conducting fundamental research on glutamate receptor function and central nervous system signaling pathways.

Basic Information

Product Name	Dl-2-Amino-7-Phosphonoheptanoic Acid
CAS No.	78966-69-5
Molecular Formula	C7H16NO5P
Molecular Weight	225.18 g/mol
Synonyms	DL-AP7; DL-2-Amino-7-phosphonoheptanoate; (±)-2-Amino-7-phosphonoheptanoic acid; APV (related analog); NMDA receptor antagonist AP7; DL-2-Amino-7-phosphonopimelic acid (common misnomer); 2-Amino-7-phosphono-heptanoic acid, DL-; Heptanoic acid, 2-amino-7-phosphono-, DL-
EINECS	Contact for details

Quality Control

Our Dl-2-Amino-7-Phosphonoheptanoic Acid is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and specific tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant in the container and storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.