Description

2'(3')-o-(Glycyl)Guanosine-5'-(o-Methylphosphate) is a chemically modified nucleoside derivative, specifically a glycyl ester of guanosine monophosphate. This compound is of significant value as a key building block and intermediate in the synthesis of oligonucleotides and nucleotide analogs for advanced research and therapeutic development. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic institutions engaged in nucleic acid chemistry, antisense technology, and the development of novel diagnostic probes.

Application

• Oligonucleotide Synthesis: Serves as a crucial phosphoramidite or solid-phase synthesis intermediate for constructing modified RNA and DNA strands.
• Antisense & siRNA Research: Used in the development of stabilized antisense oligonucleotides and small interfering RNA (siRNA) with enhanced nuclease resistance and cellular uptake.
• Prodrug Development: Acts as a promoiety in the design of nucleotide prodrugs, improving the pharmacokinetic properties of antiviral and anticancer agents.
• Bioconjugation & Labeling: The glycyl moiety provides a handle for further chemical modification, enabling site-specific conjugation with fluorophores, peptides, or other targeting molecules.
• Enzyme Substrate Studies: Utilized as a substrate or inhibitor in biochemical assays to study the activity of kinases, polymerases, and other nucleotide-processing enzymes.
• Structural Biology: Employed in X-ray crystallography and NMR studies to investigate nucleic acid-protein interactions and enzyme mechanisms.

Basic Information

Product Name	2'(3')-o-(Glycyl)Guanosine-5'-(o-Methylphosphate)
CAS No.	78900-84-2
Molecular Formula	C17H23N7O10P
Molecular Weight	516.38 g/mol
Synonyms	Glycyl-Guanosine Methylphosphate; Guanosine, 2'(or 3')-O-[N-(glycyl)]-, 5'-(methyl phosphate); 2'/3'-O-Glycyl-guanosine-5'-methylphosphate; 5'-O-Methylphosphono-2'(3')-O-glycylguanosine; N-Glycyl-2'(3')-O-guanosine methylphosphonate; GMP Glycyl Ester (Methylphosphate); Nucleotide-Glycine Conjugate
EINECS	Contact for details

Quality Control

Our production of 2'(3')-o-(Glycyl)Guanosine-5'-(o-Methylphosphate) adheres to stringent quality protocols suitable for research and development applications. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as HPLC purity, NMR confirmation, and moisture content are provided to guarantee material integrity for your critical synthetic workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.