Description

2,5-Dichloropyridine-3-Carbonyl Chloride is a highly reactive and versatile chemical intermediate characterized by its acid chloride functionality on a dichlorinated pyridine ring. This compound matters for its critical role in the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where it serves as a key building block for active ingredients. It is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries for constructing novel compounds and scaling up production processes.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging the pyridine core for biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in metal-catalyzed cross-coupling reactions and other catalytic processes.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials.
• Custom Synthesis and Contract Manufacturing: A valuable reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving diverse client projects.
• Chemical Research & Development: Fundamental reagent for exploring new chemical reactions and synthesizing novel heterocyclic compounds in academic and industrial labs.

Basic Information

Product Name	2,5-Dichloropyridine-3-Carbonyl Chloride
CAS No.	78686-87-0
Molecular Formula	C7H2Cl3NO
Molecular Weight	230.46 g/mol
Synonyms	3-Chlorocarbonyl-2,5-dichloropyridine; 2,5-Dichloronicotinoyl Chloride; 2,5-Dichloropyridine-3-carboxylic Acid Chloride; 3-Pyridinecarbonyl chloride, 2,5-dichloro-; 2,5-Dichloro-3-pyridinecarbonyl chloride; 2,5-Dichloro-3-(chloroformyl)pyridine
EINECS	Contact for details

Quality Control

Our 2,5-Dichloropyridine-3-Carbonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and reacts with moisture and strong bases. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.