Description

1-β-Arabinofuranosyl-5-Butyluracil-5'-Triphosphate is a modified nucleoside triphosphate analog, a critical building block for advanced biochemical research and development. Its primary value lies in its role as a substrate for DNA/RNA polymerases, enabling the study of nucleic acid structure, function, and enzymatic mechanisms. This compound is essential for researchers in pharmaceutical development, molecular biology, and enzymology, particularly for investigating antiviral and anticancer nucleotide-based therapies.

Application

• Enzymatic Substrate for Polymerases: Used as a modified nucleotide triphosphate (NTP) in in vitro transcription and PCR-based applications to study enzyme kinetics and fidelity.
• Antiviral Research: Serves as a key intermediate or probe in the development and mechanistic study of nucleoside analog antiviral agents.
• Molecular Probe Development: Incorporated into oligonucleotides to create labeled probes for studying nucleic acid-protein interactions and diagnostic assays.
• Biochemical Mechanism Studies: Utilized to investigate the structure-activity relationships (SAR) of nucleotide analogs and their incorporation into nucleic acid chains.
• High-Throughput Screening (HTS): Acts as a substrate in enzymatic assays for drug discovery platforms targeting viral polymerases or other nucleic acid-processing enzymes.

Basic Information

Product Name	1-β-Arabinofuranosyl-5-Butyluracil-5'-Triphosphate
CAS No.	78524-95-5
Molecular Formula	C₁₈H₂₈N₃O₁₆P₃
Molecular Weight	659.35 g/mol
Synonyms	5-Butyl-araUTP; 5-Butyl-1-β-D-arabinofuranosyluracil 5'-triphosphate; ara-5-Butyl-UTP; 1-β-D-Arabinofuranosyl-5-butyluracil 5'-triphosphate; 5-n-Butyl-araUTP; Modified Nucleoside Triphosphate; Nucleotide Analog Triphosphate; 5-Butyl-arabinosyluracil triphosphate
EINECS	Contact for details

Quality Control

Our 1-β-Arabinofuranosyl-5-Butyluracil-5'-Triphosphate is produced under stringent conditions suitable for research applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and identity confirmation by spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term stability, store desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.