Description

Potassium Guaiacolsulfonate Hemihydrate is an organosulfur potassium salt derivative of guaiacol, widely recognized for its expectorant and mucolytic properties. This high-purity pharmaceutical intermediate is critical for ensuring the efficacy and safety of final drug formulations in respiratory therapeutics. It is primarily required by manufacturers in the pharmaceutical industry for producing cough syrups, lozenges, and other medicinal products designed to alleviate bronchial congestion.

Application

• Active Pharmaceutical Ingredient (API) in expectorant and mucolytic formulations.
• Key intermediate for the synthesis of cough suppressants and cold medications.
• Manufacturing of syrups and oral solutions for respiratory tract conditions.
• Production of medicated lozenges and tablets.
• Research and development of new bronchodilator and anti-asthmatic drug candidates.
• Used in veterinary pharmaceuticals for treating respiratory issues in animals.

Basic Information

Product Name	Potassium Guaiacolsulfonate Hemihydrate
CAS No.	78247-49-1
Molecular Formula	C7H7KO5S · ½H2O
Molecular Weight	245.30 g/mol (hemihydrate)
Synonyms	Potassium Guaiacolsulfonate; Guaiacol Potassium Sulfonate; Potassium 2-Methoxyphenol-4-sulfonate Hemihydrate; Thiocol; Sulfogaiacol; Kaliumguajacolsulfonat; Guaiacolsulfonic Acid Potassium Salt; 2-Methoxy-5-hydroxybenzenesulfonic Acid Potassium Salt Hemihydrate
EINECS	Contact for details

Quality Control

Our Potassium Guaiacolsulfonate Hemihydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profile. Certificates of Analysis (COA) documenting compliance with relevant pharmacopeial standards (such as USP/EP) are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	3.0% - 4.5% (hemihydrate)
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Microbial Limits	Meets Ph. Eur. / USP criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.