Description

3-Bromo-4-Fluorobenzoyl Bromide is a versatile and highly reactive aromatic acid bromide derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its dual functionality, where the benzoyl bromide group acts as a potent acylating agent and the bromo-fluoro substitution pattern provides a handle for further selective derivatization via cross-coupling reactions. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for constructing complex molecules in drug discovery and the development of active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated and brominated aromatic systems.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the halogenated benzoyl moiety is a core structural element.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated and brominated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Polymer Chemistry: Acts as a monomer or modifying agent for introducing halogenated aromatic units into polymer backbones to alter thermal and optical properties.
• Cross-Coupling Reactions: The aryl bromide moiety makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, and Stille couplings to create biaryl structures.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D labs for exploring new synthetic methodologies and creating novel chemical entities.

Basic Information

Product Name	3-Bromo-4-Fluorobenzoyl Bromide
CAS No.	78239-66-4
Molecular Formula	C7H3Br2FO
Molecular Weight	281.91 g/mol
Synonyms	4-Fluoro-3-bromobenzoyl bromide; 3-Bromo-4-fluorobenzoic acid bromide; Benzoic acid, 3-bromo-4-fluoro-, bromide; 3-Bromo-4-fluorobenzoic acid bromide; 3-Bromo-4-fluorobenzoyl bromide; (3-Bromo-4-fluorophenyl)(oxo)methaniumyl bromide
EINECS	Contact for details

Quality Control

Our 3-Bromo-4-Fluorobenzoyl Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.