Description

Guanosine 5'-(Trihydrogen Diphosphate), 2'-Deoxy-, Disodium Salt is a high-purity nucleotide derivative, also known as dGDP disodium salt, essential for biochemical research and pharmaceutical development. This compound serves as a critical building block and substrate in enzymatic studies, particularly those involving DNA synthesis and nucleotide metabolism. It is primarily utilized by researchers in molecular biology, enzymology, and by manufacturers developing diagnostic kits and therapeutic agents.

Application

• Enzymatic Substrate: Used as a specific substrate for DNA polymerases, reverse transcriptases, and other nucleotide-dependent enzymes in kinetic and mechanistic studies.
• Biochemical Research: A key reagent in studying nucleotide metabolism, signal transduction pathways (as a precursor for dGTP), and enzyme inhibition assays.
• Diagnostic Kit Manufacturing: Incorporated as a core component in molecular diagnostic assays, including PCR and next-generation sequencing (NGS) kits.
• Pharmaceutical Intermediates: Serves as a starting material or intermediate in the synthesis of nucleotide-based antiviral or anticancer prodrugs.
• Cell Culture & Metabolism Studies: Utilized in cell-based assays to investigate the role of deoxyribonucleotides in cell proliferation and DNA repair mechanisms.

Basic Information

Product Name	Guanosine 5'-(Trihydrogen Diphosphate), 2'-Deoxy-, Disodium Salt
CAS No.	78101-74-3
Molecular Formula	C10H13N5O10P2Na2
Molecular Weight	511.16 g/mol
Synonyms	2'-Deoxyguanosine-5'-diphosphate disodium salt; dGDP disodium salt; Deoxyguanosine diphosphate disodium; 2'-Deoxy-GDP disodium; Guanosine, 2'-deoxy-, 5'-(trihydrogen diphosphate), disodium salt; 5'-dGDP-Na2; 2'-Deoxyguanosine 5'-diphosphate sodium salt
EINECS	Contact for details

Quality Control

Every batch of Guanosine 5'-(Trihydrogen Diphosphate), 2'-Deoxy-, Disodium Salt is manufactured and tested under strict quality management systems. We ensure high purity and consistency suitable for sensitive research and in-vitro diagnostic applications. Comprehensive analytical testing, including HPLC for purity and identity confirmation, is performed. Certificates of Analysis (COA) detailing all specifications are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to minimize moisture absorption. For long-term storage, consider desiccant or under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/UV)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
pH (1% Solution)	6.0 - 8.0
Endotoxin (LAL)	< 10 EU/mg
Solubility	Soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.