Description

1,3-Dioxolane-4-Carbonyl Chloride, 2,2,5-Trimethyl-, (4R-Trans)- (9Ci) is a high-purity, chiral acyl chloride derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its role as a key intermediate for introducing the protected glyceraldehyde acetonide moiety, enabling the stereoselective construction of complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for developing active pharmaceutical ingredients (APIs), nucleoside analogs, and other biologically active compounds where precise stereochemistry is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of nucleoside and nucleotide analogs used as antiviral and anticancer agents.
• Fine Chemical Synthesis: Employed in the stereoselective construction of complex natural products and specialty chemicals requiring the (R)-glyceraldehyde acetonide skeleton.
• API Development: Used in research and process chemistry for building blocks in active pharmaceutical ingredient (API) candidates, especially those targeting metabolic pathways.
• Asymmetric Synthesis: Serves as a chiral precursor for introducing stereocenters in catalytic asymmetric reactions and fragment coupling strategies.
• Carbohydrate Chemistry: Utilized in the synthesis of modified sugars and glycomimetics for biochemical research and drug discovery.
• Material Science Research: Potential intermediate for creating chiral monomers or ligands used in advanced polymeric materials and catalysts.

Basic Information

Item	Details
Product Name	1,3-Dioxolane-4-Carbonyl Chloride, 2,2,5-Trimethyl-, (4R-Trans)- (9Ci)
CAS No.	78086-73-4
Molecular Formula	C7H11ClO3
Molecular Weight	178.62 g/mol
Synonyms	(4R)-2,2,5-Trimethyl-1,3-dioxolane-4-carbonyl chloride; (R)-(-)-2,2,5-Trimethyl-1,3-dioxolane-4-carbonyl chloride; (R)-2,2,5-Trimethyl-1,3-dioxolane-4-carbonyl chloride; (R)-(-)-2,2,5-Trimethyl-4-chloroformyl-1,3-dioxolane; (R)-Glyceraldehyde Acetonide Carbonyl Chloride; (R)-Glyceraldehyde Acetonide Chloride; (R)-1,2-Isopropylidene Glyceraldehyde Carbonyl Chloride; (4R)-2,2,5-Trimethyl-4-(chlorocarbonyl)-1,3-dioxolane
EINECS	Contact for details

Quality Control

Our 1,3-Dioxolane-4-Carbonyl Chloride, 2,2,5-Trimethyl-, (4R-Trans)- (9Ci) is produced under strict quality control protocols to ensure high chemical and chiral purity suitable for demanding synthetic applications. Each batch is characterized by advanced analytical techniques including HPLC, GC, and NMR to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.