Description

1-NH2-cGMP Sodium Salt is a chemically modified nucleotide analog, specifically a sodium salt derivative of 8-amino cyclic guanosine monophosphate. This compound is a crucial biochemical tool and synthetic intermediate in life science research and pharmaceutical development. It is primarily utilized by researchers and manufacturers in the fields of molecular biology, signal transduction studies, and as a precursor for novel therapeutic agents.

Application

• Biochemical Research: Acts as a stable analog and research tool for studying cyclic nucleotide-dependent signaling pathways, particularly those involving cGMP.
• Pharmaceutical Intermediates: Serves as a key synthetic building block for the development of novel drug candidates targeting phosphodiesterases (PDEs) and other nucleotide-binding proteins.
• Enzyme Substrate/Analog: Used in enzymatic assays and as a substrate analog for protein kinases, guanylyl cyclases, and other nucleotide-metabolizing enzymes.
• Cell Signaling Studies: Employed in cellular assays to investigate the role of cGMP in processes like vasodilation, phototransduction, and neuronal communication.
• Probe Development: A precursor for the synthesis of fluorescently labeled or affinity-tagged nucleotide probes for imaging and proteomics.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for pharmaceutical development.

Basic Information

Item	Details
Product Name	1-NH2-cGMP Sodium Salt
CAS No.	78033-42-8
Molecular Formula	C10H12N6NaO7P
Molecular Weight	382.20 g/mol
Synonyms	8-Amino-cGMP Sodium Salt; 8-Aminoguanosine 3',5'-cyclic monophosphate sodium salt; 8-Amino-cyclic GMP sodium salt; 8-NH2-cGMP Na; 8-Amino-3',5'-cyclic GMP sodium salt; 1-Amino-cGMP Sodium Salt (common numbering variation); 8-Amino-cyclic guanosine monophosphate sodium salt
EINECS	Contact for details

Quality Control

Our 1-NH2-cGMP Sodium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) with detailed chromatographic data are provided to ensure traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
pH (1% Solution)	6.0 - 8.0
Heavy Metals	≤ 20 ppm
Solvent Residues (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.