Description

1-Me-Cgmp Sodium Salt is a chemically modified nucleotide analog of significant interest in biochemical research and pharmaceutical development. This compound serves as a crucial tool for studying cyclic nucleotide signaling pathways and enzyme mechanisms, particularly phosphodiesterases and protein kinases. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in signal transduction research, drug discovery, and the development of diagnostic assays.

Application

• Biochemical Research: As a substrate or inhibitor in enzymatic studies of phosphodiesterases (PDEs) to investigate cyclic nucleotide metabolism and signaling.
• Pharmaceutical R&D: A key intermediate or reference standard in the discovery and development of novel therapeutics targeting cyclic nucleotide pathways.
• Cell Signaling Studies: Used to modulate intracellular second messenger levels (cGMP) in cell-based assays to study downstream physiological effects.
• Diagnostic Assay Development: Employed in the formulation of kits and reagents for measuring enzyme activity or for use as a calibration standard in analytical methods.
• Enzyme Kinetics: Essential for determining kinetic parameters (Km, Vmax) and inhibition constants (Ki) for relevant target enzymes.
• Academic Research: Fundamental tool in university laboratories for graduate and postdoctoral research in molecular biology, pharmacology, and cell biology.

Basic Information

Product Name	1-Me-Cgmp Sodium Salt
CAS No.	78033-41-7
Molecular Formula	C11H13N5NaO7P
Molecular Weight	389.21 g/mol
Synonyms	1-Methyl-cGMP sodium salt; 1-Methylguanosine 3',5'-cyclic monophosphate sodium salt; 1-Methyl-cyclic GMP sodium salt; N1-Methyl-cGMP sodium salt; 1-Me-cGMP Na; Sodium 1-methyl-3',5'-cyclic guanylate; 1-Methyl-cyclic guanosine monophosphate sodium salt
EINECS	Contact for details

Quality Control

Our 1-Me-Cgmp Sodium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reproducible and reliable results for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the primary container under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.