Description

2-Amino-2-Methylpropanoyl Chloride is a versatile and highly reactive organic building block, essential for introducing the 2-aminoisobutyryl moiety into complex molecular structures. Its primary value lies in its role as a key intermediate for the synthesis of peptides, peptidomimetics, and active pharmaceutical ingredients (APIs), enabling precise control over molecular architecture. This compound is critically needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel compounds and fine-tuning material properties.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of peptides, peptidomimetics, and active pharmaceutical ingredients (APIs), particularly those requiring sterically hindered amino acid derivatives.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators that incorporate the 2-aminoisobutyric acid (Aib) scaffold.
• Polymer Chemistry: Serves as a monomer or modifying agent for creating specialized polyamides, polyurethanes, and other polymers with enhanced thermal stability or specific functional properties.
• Bioconjugation & Linker Chemistry: Employed in the development of chemical linkers and probes for bioconjugation applications in diagnostics and biochemical research.
• Organic Synthesis Reagent: Acts as an acylating agent for amines and alcohols, facilitating the introduction of the tert-butyl glycine-like structure in complex organic molecules.
• Material Science Research: Utilized in the development of novel organic frameworks, coatings, and advanced materials with tailored surface characteristics.

Basic Information

Product Name	2-Amino-2-Methylpropanoyl Chloride
CAS No.	78002-19-4
Molecular Formula	C4H8ClNO
Molecular Weight	121.56 g/mol
Synonyms	2-Amino-2-methylpropanoyl chloride; 2-Aminoisobutyryl chloride; 2-Methyl-2-aminopropanoyl chloride; (Amino-dimethyl-acetyl) chloride; Aib-Cl; 2-Amino-2-methyl-propionyl chloride; α-Aminoisobutyryl chloride; 2-Amino-2-methylpropanoic acid chloride
EINECS	Contact for details

Quality Control

Our 2-Amino-2-Methylpropanoyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and titration methods, to ensure high purity and consistency suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases, oxidizers, and moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (Karl Fischer)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.