Description

(4-Trifluoromethyl-Phenyl)-Phosphonic Acid Diethyl Ester is a high-value organophosphorus compound characterized by its unique trifluoromethylphenyl group. This structure makes it a versatile intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs), where the introduction of fluorine atoms can dramatically alter biological activity and material properties. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with enhanced efficacy and stability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting kinase inhibition or requiring fluorinated motifs for improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators where the phosphonic ester and trifluoromethyl groups contribute to biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for phosphonate-based ligands used in transition metal catalysis, facilitating various cross-coupling and other organic transformations.
• Material Science Research: Employed in the development of flame retardants, metal surface treatment agents, and specialty polymers where phosphorus-containing monomers are required.
• Chemical Synthesis Intermediate: A versatile reagent for introducing the (4-trifluoromethylphenyl)phosphonate moiety into more complex molecular architectures via further functionalization.

Basic Information

Product Name	(4-Trifluoromethyl-Phenyl)-Phosphonic Acid Diethyl Ester
CAS No.	77918-46-8
Molecular Formula	C11H14F3O3P
Molecular Weight	282.20 g/mol
Synonyms	Diethyl (4-(Trifluoromethyl)phenyl)phosphonate; Diethyl P-(α,α,α-Trifluoro-p-tolyl)phosphonate; (4-Trifluoromethylphenyl)phosphonic Acid Diethyl Ester; Phosphonic Acid, P-[4-(Trifluoromethyl)phenyl]-, Diethyl Ester; Diethyl (4-Trifluoromethylphenyl)phosphonate; Diethyl (4-Trifluoromethylbenzyl)phosphonate (common misnomer); 77918-46-8; EINECS likely not assigned

Quality Control

Our production of (4-Trifluoromethyl-Phenyl)-Phosphonic Acid Diethyl Ester adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including GC, HPLC, NMR, and MS to confirm identity and quantify purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.