Description

Uridine, 2'-Deoxy-5-(Phenylethynyl)- is a modified nucleoside analog, a key building block in medicinal chemistry and life science research. This compound is valued for its role as a versatile intermediate in the synthesis of novel therapeutic agents and biochemical probes. It is primarily required by pharmaceutical R&D departments, biotechnology companies, and academic research institutions focused on antiviral drug discovery, oligonucleotide synthesis, and molecular biology studies.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of nucleoside-based antiviral and anticancer drug candidates.
• Biochemical Research: Used as a modified building block for oligonucleotide synthesis to study nucleic acid structure, function, and interactions.
• Probe Development: Serves as a base for developing fluorescent or affinity-labeled probes for diagnostic assays and cellular imaging.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the pharmacokinetic properties of nucleoside analogs.
• Enzyme Substrate/Inhibitor Studies: Utilized to investigate the activity and inhibition of kinases, polymerases, and other nucleic acid-metabolizing enzymes.

Basic Information

Product Name	Uridine, 2'-Deoxy-5-(Phenylethynyl)-
CAS No.	77887-20-8
Molecular Formula	C₁₇H₁₆N₂O₅
Molecular Weight	328.32 g/mol
Synonyms	5-(Phenylethynyl)-2'-deoxyuridine; 2'-Deoxy-5-(phenylethynyl)uridine; dU-PhE; EdU analog; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(2-phenylethynyl)pyrimidine-2,4-dione
EINECS	Contact for details

Quality Control

Our Uridine, 2'-Deoxy-5-(Phenylethynyl)- is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.