Description

5-(1-Pentynyl)-2'-Deoxyuridine is a modified nucleoside analog, a key building block in advanced biochemical research and pharmaceutical development. This compound matters for its role as a versatile intermediate in the synthesis of oligonucleotides and probes, enabling critical studies in molecular biology and targeted drug discovery. It is primarily needed by research institutions, diagnostic developers, and pharmaceutical companies working on antiviral agents, genetic research tools, and novel therapeutic modalities.

Application

• Oligonucleotide Synthesis: A crucial phosphoramidite precursor for constructing modified DNA strands with specific functionalization.
• Antiviral Research: Serves as a core scaffold in the development of nucleoside analog-based antiviral prodrugs.
• Molecular Probes: Used to create labeled probes for fluorescence in situ hybridization (FISH) and other detection techniques.
• Bioconjugation: The pentynyl side chain allows for efficient click chemistry (e.g., CuAAC) conjugation with azide-bearing molecules like dyes or carriers.
• Enzyme Substrate Studies: Acts as a substrate or inhibitor for studying thymidine kinase and other nucleoside-metabolizing enzymes.
• Precision Medicine Tools: Incorporated into diagnostic assays and therapeutic oligonucleotides for personalized medicine approaches.

Basic Information

Product Name	5-(1-Pentynyl)-2'-Deoxyuridine
CAS No.	77887-18-4
Molecular Formula	C14H18N2O5
Molecular Weight	294.30 g/mol
Synonyms	5-(Pent-1-yn-1-yl)-2'-deoxyuridine; 5-(1-Pentyn-1-yl)-2'-deoxyuridine; 2'-Deoxy-5-(1-pentynyl)uridine; 5-Pent-1-ynyl-2'-deoxyuridine; dU-Pentyne; 5-Alkynyl-2'-deoxyuridine derivative; 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(pent-1-yn-1-yl)pyrimidine-2,4(1H,3H)-dione
EINECS	Contact for details

Quality Control

Our 5-(1-Pentynyl)-2'-Deoxyuridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with full batch traceability are provided to guarantee reproducibility and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccant use and storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.