Description

5'-o-[Bis(2,2-Dimethyl-1-Aziridinyl)Phosphinyl]Thymidine is a specialized nucleoside phosphoramidite derivative, a critical building block in the synthesis of oligonucleotides. This high-purity intermediate is essential for researchers and manufacturers requiring precise control over nucleic acid sequence construction. It is primarily utilized in the pharmaceutical, biotechnology, and life science research sectors for applications in antisense therapy, diagnostic probe development, and synthetic biology.

Application

• Oligonucleotide Synthesis: Serves as a key phosphoramidite monomer in solid-phase automated DNA/RNA synthesizers.
• Antisense Drug Development: Used in the research and production of antisense oligonucleotides (ASOs) for therapeutic applications.
• Diagnostic Probe Manufacture: Essential for creating labeled probes used in PCR, sequencing, and microarray technologies.
• Synthetic Biology: A building block for constructing novel genetic circuits and engineered nucleic acids.
• Research & Development: Employed in academic and industrial R&D for studying nucleic acid chemistry and function.
• Pharmaceutical Intermediates: Acts as a precursor in the multi-step synthesis of complex nucleoside-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	5'-o-[Bis(2,2-Dimethyl-1-Aziridinyl)Phosphinyl]Thymidine
CAS No.	77887-10-6
Molecular Formula	C18H28N5O7P
Molecular Weight	457.42 g/mol
Synonyms	5'-O-[Bis(2,2-dimethylaziridin-1-yl)phosphinyl]thymidine; Thymidine 5'-[bis(2,2-dimethyl-1-aziridinyl)phosphinate]; Thymidine 5'-phosphoramidite (2,2-dimethylaziridine); 5'-DMT-thymidine phosphoramidite (related protected form); T-Phosphoramidite; Nucleoside Phosphoramidite Monomer; DNA Synthesis Reagent
EINECS	Contact for details

Quality Control

Our 5'-o-[Bis(2,2-Dimethyl-1-Aziridinyl)Phosphinyl]Thymidine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive oligonucleotide synthesis. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability and prevent decomposition. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Purity (HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5%
Solubility	Soluble in anhydrous acetonitrile, DCM

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.