Description

Thymidine 5'-[Di(1-Aziridinyl)Phosphinic Acid] is a specialized nucleoside phosphoramidite derivative, a critical building block in synthetic organic chemistry and oligonucleotide synthesis. This compound matters for its role as a key intermediate in the preparation of modified DNA and RNA sequences, enabling advanced research in molecular biology and therapeutic development. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on antisense oligonucleotides, siRNA, and other nucleic acid-based technologies.

Application

• Oligonucleotide Synthesis: Serves as a vital phosphoramidite monomer for the solid-phase synthesis of thymidine-containing DNA and RNA strands.
• Antisense Drug Development: Used in the research and production of antisense oligonucleotides designed for targeted gene silencing.
• siRNA and miRNA Research: Acts as a precursor for creating modified siRNA and miRNA constructs to enhance stability and cellular uptake.
• Molecular Probes and Diagnostics: Employed in the fabrication of labeled nucleic acid probes for diagnostic assays and genomic research.
• Bioconjugation Chemistry: The reactive aziridinyl groups can be utilized for cross-linking or attaching other functional molecules to nucleic acids.
• Academic & Industrial R&D: A fundamental reagent for exploring novel nucleic acid chemistries and developing next-generation genetic medicines.

Basic Information

Product Name	Thymidine 5'-[Di(1-Aziridinyl)Phosphinic Acid]
CAS No.	77887-09-3
Molecular Formula	C14H22N5O6P
Molecular Weight	387.33 g/mol
Synonyms	5'-O-[Bis(1-aziridinyl)phosphinyl]thymidine; Thymidine 5'-(di(1-aziridinyl)phosphinate); Thymidine 5'-phosphorodiamidite; 1-[5-O-[Bis(1-aziridinyl)phosphinyl]-2-deoxy-β-D-ribofuranosyl]-5-methyl-2,4(1H,3H)-pyrimidinedione; Thymidine Phosphorodiamidite; Aziridine Phosphinyl Thymidine Derivative
EINECS	Contact for details

Quality Control

Our Thymidine 5'-[Di(1-Aziridinyl)Phosphinic Acid] is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive oligonucleotide synthesis. Certificates of Analysis (COA) with detailed batch-specific results are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opened to prevent degradation. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.