Description

Doxazosin Mesylate CAS NO 77883-43-3 is a high-purity pharmaceutical active ingredient, specifically a quinazoline derivative and selective α-1 adrenergic receptor antagonist. This compound is critical for the formulation of antihypertensive and benign prostatic hyperplasia (BPH) medications, ensuring therapeutic efficacy and batch-to-batch consistency. It is essential for pharmaceutical manufacturers, R&D laboratories, and contract development and production organizations (CDMOs) involved in cardiovascular and urological drug development.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the manufacture of finished dosage forms for the treatment of hypertension and benign prostatic hyperplasia (BPH).
• Generic Drug Formulation: Serves as the key therapeutic component in generic versions of doxazosin-based medications.
• Clinical Research & Development: Used in preclinical and clinical studies for developing new therapeutic applications or combination therapies.
• Reference Standard: Employed as a high-purity standard in analytical laboratories for quality control, method development, and validation (HPLC, LC-MS).
• Biochemical Research: Utilized in pharmacological studies to investigate α-adrenergic receptor mechanisms and signal transduction pathways.

Basic Information

Product Name	Doxazosin Mesylate
CAS No.	77883-43-3
Molecular Formula	C23H25N5O5 • CH4O3S
Molecular Weight	547.59 g/mol
Synonyms	Doxazosin Methanesulfonate; UK-33274; Doxazosin Mesilate; 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazine Methanesulfonate; Cardura (brand name mesylate salt); Alfadil; Doxacard; Doxapress; Doxazosin Mesylate USP
EINECS	Contact for details

Quality Control

Our Doxazosin Mesylate is manufactured under strict quality management systems. Each batch is tested to meet or exceed relevant pharmacopeial standards, including USP (United States Pharmacopeia) and EP (European Pharmacopoeia) monographs where applicable. Comprehensive testing includes identification, assay, impurity profiling, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment away from direct light exposure to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0% Any individual impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.