Description

3β,6β-Bis[(Trimethylsilyl)Oxy]Pregn-4-En-20-One is a high-purity, protected steroid derivative, specifically a pregnane derivative with trimethylsilyl (TMS) ether groups at the 3β and 6β positions. This compound serves as a crucial synthetic intermediate in the production of more complex steroid-based pharmaceuticals and fine chemicals. Its primary value lies in enabling precise chemical transformations while protecting sensitive hydroxyl functionalities, which is essential for researchers and manufacturers in advanced organic synthesis. This makes it particularly relevant for the pharmaceutical, biotechnology, and academic research sectors focused on developing novel therapeutic agents and conducting metabolic studies.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex steroid hormones and their analogs for therapeutic use.
• Research & Development: Used in academic and industrial R&D laboratories for studying steroid metabolism, structure-activity relationships (SAR), and developing new synthetic pathways.
• Fine Chemical Synthesis: Employed as a protected precursor in the production of high-value specialty chemicals and advanced materials.
• Reference Standard: Serves as a certified reference material (CRM) or analytical standard for quality control and method validation in analytical laboratories.
• Bioconjugate Chemistry: Potential use in creating steroid-protein conjugates for immunological and diagnostic applications.

Basic Information

Product Name	3β,6β-Bis[(Trimethylsilyl)Oxy]Pregn-4-En-20-One
CAS No.	77828-36-5
Molecular Formula	C₂₉H₅₂O₃Si₂
Molecular Weight	504.90 g/mol
Synonyms	3β,6β-Bis(trimethylsilyloxy)pregn-4-en-20-one; Pregn-4-ene-3β,6β-diol 20-one bis(trimethylsilyl) ether; 3β,6β-Bis-O-(trimethylsilyl)pregn-4-en-20-one; 20-Oxopregn-4-ene-3β,6β-diyl bis(trimethylsilyl) ether; 3β,6β-Di(trimethylsiloxy)pregn-4-en-20-one; 3β,6β-Bis(trimethylsiloxy)-4-pregnen-20-one; 3β,6β-Bis[(trimethylsilyl)oxy]-4-pregnen-20-one
EINECS	Contact for details

Quality Control

Our 3β,6β-Bis[(Trimethylsilyl)Oxy]Pregn-4-En-20-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical intermediates and research chemicals. Certificates of Analysis (COA) detailing specific results from HPLC, NMR, and other relevant tests are provided with every shipment. We support compliance with cGMP and ICH guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.