Description

Cyclopropanecarbonyl Chloride, 3-Ethynyl-2,2-Dimethyl-, (1R-Trans)- (9Ci) is a high-purity, chiral building block of significant interest in advanced organic synthesis. Its unique structure, featuring both a reactive acid chloride group and a terminal alkyne, makes it a versatile intermediate for constructing complex molecular architectures. This compound is particularly valuable for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides that require specific stereochemistry for optimal activity.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of advanced polymers and functional materials where the cyclopropane and alkyne functionalities impart specific properties.
• Peptide Mimetics and Bioconjugation: The reactive acid chloride group enables efficient coupling to amines, useful for creating peptide analogs or bioconjugation linkers.
• Chemical Biology Probes: Utilized to develop molecular probes for studying biological systems, leveraging the "click chemistry" capability of the alkyne group.

Basic Information

Product Name	Cyclopropanecarbonyl Chloride, 3-Ethynyl-2,2-Dimethyl-, (1R-Trans)- (9Ci)
CAS No.	77789-81-2
Molecular Formula	C8H9ClO
Molecular Weight	156.61 g/mol
Synonyms	(1R,3S)-3-Ethynyl-2,2-dimethylcyclopropanecarbonyl chloride; (1R-trans)-3-Ethynyl-2,2-dimethylcyclopropanecarboxylic acid chloride; trans-3-Ethynyl-2,2-dimethylcyclopropanecarbonyl chloride; 3-Ethynyl-2,2-dimethylcyclopropanecarboxylic acid chloride (1R-trans); Chiral Cyclopropane Acid Chloride; 77789-81-2
EINECS	Contact for details

Quality Control

Every batch of Cyclopropanecarbonyl Chloride, 3-Ethynyl-2,2-Dimethyl-, (1R-Trans)- (9Ci) is produced under strict quality management systems. We employ advanced analytical techniques, including chiral HPLC, GC, and NMR, to ensure high enantiomeric purity and chemical identity. A comprehensive Certificate of Analysis (COA) detailing purity, chiral excess, and impurity profiles is provided with each shipment to guarantee reliable performance in your sensitive synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at temperatures between 2°C and 8°C (refrigerated) for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.