Description

Cyclopropanecarbonyl Chloride, 3-(2-Chloro-2-Fluoroethenyl)-2,2-Dimethyl-, [1R-[1Alpha,3Beta(Z)]]- (9Ci) is a high-purity, stereochemically defined organofluorine building block essential for advanced synthetic chemistry. This compound is valued for its unique cyclopropane and fluoroalkene functionalities, which are critical for introducing structural complexity and modulating physicochemical properties in target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS, antiviral, or anti-inflammatory therapies.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the cyclopropane and fluorine motifs can enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for specialty polymers or liquid crystals, leveraging its rigid molecular structure to influence material properties.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds or molecular probes for studying biological mechanisms and interactions.
• Process Chemistry & Scale-up: Utilized in route scouting and optimization for the commercial-scale production of fine chemicals and active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	Cyclopropanecarbonyl Chloride, 3-(2-Chloro-2-Fluoroethenyl)-2,2-Dimethyl-, [1R-[1Alpha,3Beta(Z)]]- (9Ci)
CAS No.	77789-75-4
Molecular Formula	C8H9Cl2FO
Molecular Weight	211.06 g/mol
Synonyms	(1R,3Z)-3-(2-Chloro-2-fluorovinyl)-2,2-dimethylcyclopropanecarbonyl chloride; (1R-cis)-3-[(Z)-2-Chloro-2-fluorovinyl]-2,2-dimethylcyclopropanecarboxylic acid chloride; 2,2-Dimethyl-3-[(Z)-2-chloro-2-fluorovinyl]cyclopropanecarboxylic acid chloride, (1R,3S)-rel-; Pyrethroid acid chloride intermediate; (Z)-(1R,3R)-3-(2-Chloro-2-fluorovinyl)-2,2-dimethylcyclopropanecarbonyl chloride
EINECS	Contact for details

Quality Control

Every batch of our Cyclopropanecarbonyl Chloride, 3-(2-Chloro-2-Fluoroethenyl)-2,2-Dimethyl-, [1R-[1Alpha,3Beta(Z)]]- (9Ci) is produced and tested under a strict quality management system. We ensure high chiral purity and chemical integrity through advanced analytical techniques including chiral HPLC, GC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and moisture-sensitive nature, the container should be kept under an inert atmosphere (e.g., nitrogen or argon) after opening. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.