Description

Cyclopropanecarbonyl Chloride, 3-(Cyclobutylidenemethyl)-2,2-Dimethyl-, (1R-Trans)- (9Ci) is a high-purity, chiral building block of significant interest in advanced organic synthesis. Its complex, functionalized cyclopropane and cyclobutene architecture makes it a valuable precursor for constructing novel molecular scaffolds with precise stereochemistry. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of new active ingredients and complex intermediates. The CAS number for this compound is 77789-65-2.

Application

This specialized chiral synthon is engineered for high-value synthetic applications where structural complexity and stereochemical control are paramount.

• Pharmaceutical Intermediate: A key chiral building block for the research and development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Used in the creation of advanced, stereochemically-defined intermediates for new generation herbicides, fungicides, and insecticides.
• Methodology Development: Serves as a challenging substrate in academic and industrial research for developing new asymmetric synthesis and ring-forming reactions.
• Ligand and Catalyst Preparation: Employed in the synthesis of complex, chiral ligands and organocatalysts for stereoselective transformations.
• Material Science Research: Potential precursor for specialty monomers or additives aimed at creating polymers with unique thermal or mechanical properties.

Basic Information

Item	Details
Product Name	Cyclopropanecarbonyl Chloride, 3-(Cyclobutylidenemethyl)-2,2-Dimethyl-, (1R-Trans)- (9Ci)
CAS No.	77789-65-2
Molecular Formula	C11H15ClO
Molecular Weight	198.69 g/mol
Synonyms	(1R,3S)-3-[(Cyclobutylidene)methyl]-2,2-dimethylcyclopropanecarbonyl chloride; (1R-trans)-3-(Cyclobutylidenemethyl)-2,2-dimethylcyclopropanecarboxylic acid chloride; trans-3-(Cyclobutylidenemethyl)-2,2-dimethylcyclopropanecarbonyl chloride; (1R,3S)-3-(Cyclobutylidenemethyl)-2,2-dimethyl-1-cyclopropanecarbonyl chloride
EINECS	Contact for details

Quality Control

Every batch of our Cyclopropanecarbonyl Chloride, 3-(Cyclobutylidenemethyl)-2,2-Dimethyl-, (1R-Trans)- (9Ci) is produced and controlled under a strict quality management system. We employ advanced analytical techniques, including chiral HPLC, GC, and NMR, to ensure exceptional enantiomeric purity and chemical identity. A comprehensive Certificate of Analysis (COA) detailing purity, chiral excess, and impurity profiles is provided with each shipment to guarantee batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container under an inert atmosphere (e.g., nitrogen or argon), protected from light, and stored in a cool, dry place. Due to its hygroscopic and acid chloride nature, it must be kept away from moisture, strong bases, and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability. Handle and store only in compatible, dry glass or fluorinated polymer containers.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (Karl Fischer)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.