Description

Cyclopropanecarbonyl Chloride, 3-Ethynyl-2,2-Dimethyl-, (1R-Cis)- (9Ci) is a high-purity, chiral organic intermediate of significant interest in advanced synthetic chemistry. This compound matters for its role as a key building block in the synthesis of complex, biologically active molecules, offering precise stereochemical control. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of novel therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the production of advanced, stereospecific pesticides and herbicides where the specific spatial orientation of the molecule is crucial for bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of novel monomers or functionalized polymers with tailored properties for advanced materials.
• Chemical Biology Probes: Utilized to create labeled or modified molecular probes for studying biological pathways and mechanisms.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis houses serving the pharmaceutical and biotechnology sectors.

Basic Information

Product Name	Cyclopropanecarbonyl Chloride, 3-Ethynyl-2,2-Dimethyl-, (1R-Cis)- (9Ci)
CAS No.	77723-73-0
Molecular Formula	C8H9ClO
Molecular Weight	156.61 g/mol
Synonyms	(1R,3S)-3-Ethynyl-2,2-dimethylcyclopropanecarbonyl chloride; (1R-cis)-3-Ethynyl-2,2-dimethylcyclopropanecarboxylic acid chloride; 3-Ethynyl-2,2-dimethyl-(1R,3S)-cyclopropanecarbonyl chloride; (1R,3S)-3-Ethynyl-2,2-dimethylcyclopropanecarboxylic acid chloride; trans-(1R,3S)-3-Ethynyl-2,2-dimethylcyclopropanecarbonyl chloride; (1R,3S)-rel-3-Ethynyl-2,2-dimethylcyclopropanecarbonyl chloride; Cyclopropanecarbonyl chloride, 3-ethynyl-2,2-dimethyl-, (1R,3S)-rel-
EINECS	Contact for details

Quality Control

Our Cyclopropanecarbonyl Chloride, 3-Ethynyl-2,2-Dimethyl-, (1R-Cis)- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chiral purity. Production adheres to cGMP guidelines where applicable, and each lot is supported by a comprehensive Certificate of Analysis (COA). The COA includes data for chiral purity (enantiomeric excess), chemical purity (HPLC), identity confirmation (IR, NMR), and impurity profiling to meet the stringent requirements of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its nature as an acid chloride, it is moisture-sensitive and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent hydrolysis. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.