Description

5-((Hydroxymethyl)-o-Pyrophosphoryl)Uracil is a chemically modified nucleoside derivative of significant interest in advanced biochemical research and pharmaceutical development. This compound serves as a crucial building block and a key intermediate in the synthesis of novel nucleotide analogs and prodrugs. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors for applications in antiviral and anticancer drug discovery, as well as in the study of nucleotide metabolism and enzyme mechanisms.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel antiviral and anticancer nucleotide prodrugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism and DNA/RNA synthesis pathways.
• Pro-drug Development: Employed in the design of masked nucleotide analogs to improve cellular uptake and therapeutic efficacy.
• Antiviral Agent Synthesis: Serves as a core scaffold for developing compounds targeting viral polymerases.
• Labeled Compound Production: Can be used to create isotopically labeled versions for metabolic tracing and pharmacokinetic studies.
• Life Science Reagents: Incorporated into tool compounds and assay kits for high-throughput screening and target validation.

Basic Information

Product Name	5-((Hydroxymethyl)-o-Pyrophosphoryl)Uracil
CAS No.	77431-77-7
Molecular Formula	C10H15N2O11P2
Molecular Weight	401.18 g/mol
Synonyms	5-(Hydroxymethyl)uracil O-pyrophosphate; 5-HMU-PP; 5-(Hydroxymethyl)-2,4(1H,3H)-pyrimidinedione 1-(dihydrogen diphosphate); Uracil, 5-(hydroxymethyl)-, 1-(dihydrogen diphosphate); 1-(Dihydrogen diphosphate)-5-(hydroxymethyl)uracil; 5-(Hydroxymethyl)uracil 1-diphosphate; Nucleotide analog intermediate; HMU diphosphate
EINECS	Contact for details

Quality Control

Our 5-((Hydroxymethyl)-o-Pyrophosphoryl)Uracil is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development purposes. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We support compliance with cGMP standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is hygroscopic (moisture-sensitive) and must be handled in a dry environment. For short-term use, the material may be stored desiccated at 2-8°C. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.