Description

5-(Hydroxymethyl-o-Pyrophosphoryl)Deoxyuridylate is a specialized nucleotide derivative, a key intermediate in the synthesis of modified nucleosides and nucleotides. This compound matters for its role in advanced biochemical research and pharmaceutical development, particularly in the study of DNA metabolism and antiviral/anticancer agent synthesis. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers focused on nucleotide-based therapeutics and molecular biology tools.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or intermediate in enzymatic studies related to DNA synthesis and repair pathways.
• Proteomics & Genomics: Serves as a modified nucleotide precursor for labeling and probe development in molecular diagnostics.
• Enzymology Studies: Employed to investigate the activity and inhibition of thymidylate synthase and related enzymes.
• Fine Chemical Synthesis: A high-value intermediate for custom nucleotide synthesis and contract manufacturing.
• Academic Research: Utilized in university laboratories for fundamental studies in medicinal chemistry and nucleotide biochemistry.

Basic Information

Product Name	5-(Hydroxymethyl-o-Pyrophosphoryl)Deoxyuridylate
CAS No.	77423-48-4
Molecular Formula	C10H15N2O15P3
Molecular Weight	520.13 g/mol
Synonyms	5-(Hydroxymethyl)-2'-deoxyuridine 5'-(trihydrogen diphosphate); dUMP-CH2OH-PP; 5-Hydroxymethyldeoxyuridine monophosphate pyrophosphate; 5-(Hydroxymethyl)-2'-deoxyuridylic acid pyrophosphate; HMdUMP-PP; 5-HMdUMP pyrophosphate; Nucleotide intermediate 77423-48-4; 5-(Hydroxymethyl)-dUMP pyrophosphoryl ester
EINECS	Contact for details

Quality Control

Our 5-(Hydroxymethyl-o-Pyrophosphoryl)Deoxyuridylate is produced under controlled conditions to ensure high purity and batch-to-batch consistency. Each lot undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS). We provide comprehensive Certificates of Analysis (COA) detailing all specifications. Our quality system is designed to meet the stringent requirements of research and pharmaceutical-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. For long-term storage, consider desiccant or under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.