Description

Uridine, 5-Fluoro-, 2',3'-Diacetate is a chemically modified nucleoside derivative, specifically a protected form of 5-fluorouridine. This compound is a crucial pharmaceutical intermediate and a valuable building block in organic synthesis. It is primarily used by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries for the development of antiviral and anticancer agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism.
• Antiviral Drug Development: Serves as a critical building block for prodrugs targeting viral polymerases.
• Oncology Research: Employed in the research and development of chemotherapeutic agents that interfere with RNA synthesis.
• Organic Synthesis: Protected intermediate for the selective modification of the ribose sugar moiety in nucleoside chemistry.
• Labeled Compound Synthesis: Starting material for the preparation of isotopically labeled (e.g., 13C, 15N) compounds for metabolic tracing studies.

Basic Information

Product Name	Uridine, 5-Fluoro-, 2',3'-Diacetate
CAS No.	77421-87-5
Molecular Formula	C₁₅H₁₇FN₂O₈
Molecular Weight	372.31 g/mol
Synonyms	5-Fluoro-2',3'-di-O-acetyluridine; 2',3'-Di-O-acetyl-5-fluorouridine; 5-Fluorouridine 2',3'-diacetate; 1-[(2R,3R,4R,5R)-3,4-Diacetoxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoro-1,2,3,4-tetrahydropyrimidine-2,4-dione; 5-Fluoro-2',3'-diacetyluridine; 5-FDUrd(Ac)₂
EINECS	Contact for details

Quality Control

Our Uridine, 5-Fluoro-, 2',3'-Diacetate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical research and synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.