Description

4-Chlorophenyl-5-Chloro-8-Quinolinyl Phosphorochloridate is a specialized organophosphorus compound that serves as a critical reactive intermediate in advanced chemical synthesis. Its value lies in its ability to act as a phosphorylating agent, enabling the precise construction of complex molecular architectures. This high-purity reagent is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for synthesizing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor research.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides requiring specific phosphorus-containing functional groups.
• Chemical Biology Research: Employed as a tool compound for modifying proteins, nucleotides, or other biomolecules to study biological pathways.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized phosphine or phosphate ligands used in metal-catalyzed reactions.
• Material Science: Potential monomer or cross-linking agent in the development of specialty polymers with unique properties.
• Process Chemistry: Used in scale-up and optimization of synthetic routes for commercial active pharmaceutical ingredients (APIs).

Basic Information

Product Name	4-Chlorophenyl-5-Chloro-8-Quinolinyl Phosphorochloridate
CAS No.	77181-80-7
Molecular Formula	C₁₅H₉Cl₃NO₂P
Molecular Weight	380.56 g/mol
Synonyms	5-Chloro-8-quinolyl 4-chlorophenyl phosphorochloridate; Phosphorochloridic acid, (5-chloro-8-quinolinyl)-, 4-chlorophenyl ester; 4-Chlorophenyl (5-chloro-8-quinolyl) chlorophosphate; 4-Chlorophenyl 5-chloroquinolin-8-yl phosphorochloridate; 8-Quinolinol, 5-chloro-, 4-chlorophenyl ester, chloride phosphate; (5-Chloro-8-quinolyl) 4-chlorophenyl phosphorochloridate
EINECS	Contact for details

Quality Control

Our 4-Chlorophenyl-5-Chloro-8-Quinolinyl Phosphorochloridate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the exacting standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	95.0 - 102.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.