Description

4-Hydroxyestrone-17-(o-Carboxymethyl)Oxime is a key synthetic intermediate and reference standard in steroid chemistry and pharmaceutical research. This compound matters for its role in the development and analytical validation of hormone-based therapeutics and diagnostic assays. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and manufacturers of fine chemicals for applications in endocrinology, biochemistry, and as a precursor for more complex steroid derivatives.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel steroid-based drugs and hormone analogs.
• Analytical Reference Standard: Used for method development, calibration, and quality control in HPLC, LC-MS, and other chromatographic analyses of estrogen metabolites.
• Biochemical Research: Employed in studies of estrogen metabolism, receptor binding assays, and enzymatic activity related to steroidogenesis.
• Diagnostic Reagent Manufacturing: A key component in the production of immunoassay kits for the quantitative detection of estrone and related hormones in clinical samples.
• Fine Chemical Synthesis: Acts as a precursor for the preparation of more complex, functionally modified steroid derivatives for various research applications.

Basic Information

Item	Details
Product Name	4-Hydroxyestrone-17-(o-Carboxymethyl)Oxime
CAS No.	77111-07-0
Molecular Formula	C20H25NO5
Molecular Weight	359.42 g/mol
Synonyms	4-Hydroxyestrone 17-(Carboxymethyl)oxime; 4-Hydroxyestrone-17-CMO; Estrone-4-ol-17-(O-carboxymethyl)oxime; 3-Hydroxy-1,3,5(10)-estratrien-17-one 4,17-bis(O-carboxymethyl)oxime (related); 4-OHE1-17-CMO; Estrogen metabolite derivative; 17-(Carboxymethyl)oximino-4-hydroxyestra-1,3,5(10)-trien-3-ol
EINECS	Contact for details

Quality Control

Our 4-Hydroxyestrone-17-(o-Carboxymethyl)Oxime is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.