Description

1-(tert-Butyldimethylsilyloxy)-1- is a versatile organosilicon reagent, specifically a silyl-protected intermediate, widely used in advanced organic synthesis. Its primary value lies in its ability to act as a robust protecting group for hydroxyl functionalities, enabling selective reactions in complex multi-step syntheses. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity intermediates for developing active ingredients and novel compounds.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of complex drug molecules, particularly in protecting sensitive alcohol groups during peptide and nucleoside chemistry.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides where selective protection is required.
• Fine Chemical Manufacturing: Serves as a key building block for fragrances, flavors, and specialty polymers.
• Academic & R&D Laboratories: A fundamental reagent for methodological development in organic chemistry and catalysis research.
• Process Chemistry: Employed in scalable production processes for its stability and ease of introduction/removal (desilylation).

Basic Information

Product Name	1-(tert-Butyldimethylsilyloxy)-1-
CAS No.	77086-38-5
Molecular Formula	C8H20OSi
Molecular Weight	160.33 g/mol
Synonyms	1-(tert-Butyldimethylsiloxy)-1-; TBDMS-protected intermediate; tert-Butyldimethylsilyl ether derivative; (1,1-Dimethylethyl)dimethylsilyl ether; TBDMS ether; Silicon protecting group reagent; tert-Butyldimethylsilyl (TBDMS) reagent; 1-(Tert-butyldimethylsilyloxy) compound
EINECS	Contact for details

Quality Control

Our 1-(tert-Butyldimethylsilyloxy)-1- is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles. Quality is verified against in-house specifications developed for research and industrial use. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.