Description

Phosphorochloridic Acid 2,2-Dimethyl-[1,3]Dioxolan-4-Ylmethyl Ester Methyl Ester is a specialized organophosphorus compound that serves as a critical phosphorylating and chlorinating agent in advanced chemical synthesis. Its value lies in its bifunctional reactivity, enabling the efficient construction of complex molecules, particularly in the development of pharmaceuticals and agrochemicals. This high-purity intermediate is essential for R&D chemists and process development scientists working in fine chemical and active pharmaceutical ingredient (API) manufacturing.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of nucleoside analogs, prodrugs, and other bioactive molecules requiring phosphate or phosphonate groups.
• Agrochemical Synthesis: Used in the production of advanced insecticides, herbicides, and plant growth regulators that incorporate phosphorous-based functional groups.
• Chemical Biology & Proteomics: Employed as a reagent for modifying peptides, nucleotides, and other biomolecules to study biological processes or create diagnostic tools.
• Polymer Chemistry: Acts as a monomer or cross-linking agent in the synthesis of specialty polymers with specific flame-retardant or adhesive properties.
• Ligand & Catalyst Preparation: Useful for synthesizing novel organophosphorus ligands used in asymmetric catalysis and metal complexation.
• Material Science Research: Applied in surface modification and the creation of functionalized materials for electronic or sensor applications.

Basic Information

Product Name	Phosphorochloridic Acid 2,2-Dimethyl-[1,3]Dioxolan-4-Ylmethyl Ester Methyl Ester
CAS No.	77075-54-8
Molecular Formula	C7H14ClO5P
Molecular Weight	244.61 g/mol
Synonyms	2,2-Dimethyl-1,3-dioxolane-4-methanol, cyclic methyl phosphate chloride; (4-Hydroxymethyl-2,2-dimethyl-1,3-dioxolan-4-yl)methyl methyl chlorophosphate; Methyl (2,2-dimethyl-1,3-dioxolan-4-yl)methyl chlorophosphate; Acetonide Methyl Phosphorochloridate; Glycerol Acetonide Methyl Phosphorochloridate; Phosphorochloridic Acid, (2,2-Dimethyl-1,3-dioxolan-4-yl)methyl Methyl Ester
EINECS	Contact for details

Quality Control

Every batch of Phosphorochloridic Acid 2,2-Dimethyl-[1,3]Dioxolan-4-Ylmethyl Ester Methyl Ester is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its moisture-sensitive (hygroscopic) nature, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and maintain product integrity. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Chloride Content	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.