Description

n-Bromoacetyl-3,3',5-Triiodothyronine is a key synthetic intermediate and a chemically modified derivative of the thyroid hormone triiodothyronine (T3). This compound is of significant value for research and development in the life sciences, particularly for creating labeled or conjugated hormone analogs. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on endocrinology, receptor studies, and diagnostic probe development.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of novel thyroid hormone receptor ligands and targeted drug conjugates.
• Biochemical Research: Used as a precursor for radiolabeled (e.g., 125I) or fluorescently tagged T3 analogs in receptor binding assays and cellular imaging studies.
• Proteomics & Affinity Labeling: The bromoacetyl group serves as a reactive handle for covalent attachment to proteins, peptides, or solid supports for affinity purification or cross-linking experiments.
• Diagnostic Development: Acts as a hapten for the development of immunoassays or as a component in the creation of diagnostic sensors for thyroid function.
• Chemical Biology Probes: Enables the study of thyroid hormone action and metabolism at the molecular level through activity-based protein profiling.

Basic Information

Product Name	n-Bromoacetyl-3,3',5-Triiodothyronine
CAS No.	76970-94-0
Molecular Formula	C15H10BrI3NO4
Molecular Weight	785.86 g/mol
Synonyms	Bromoacetyl-T3; N-Bromoacetyl-3,3',5-triiodo-L-thyronine; L-Thyronine, 3,3',5-triiodo-, N-bromoacetyl-; Bromoacetyl triiodothyronine; T3-Bromoacetyl; 3,3',5-Triiodothyronine N-bromoacetyl derivative; (2S)-2-(4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl)-2-[(2-bromoacetyl)amino]acetic acid
EINECS	Contact for details

Quality Control

Our n-Bromoacetyl-3,3',5-Triiodothyronine is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.