Description

Nizatidine CAS NO 76963-41-2 is a selective histamine H₂-receptor antagonist used to inhibit gastric acid secretion. This compound is a critical active pharmaceutical ingredient (API) for the formulation of effective anti-ulcer and gastroesophageal reflux disease (GERD) medications. It is essential for pharmaceutical manufacturers and research institutions developing treatments for peptic ulcers, heartburn, and other acid-related gastrointestinal disorders.

Application

• Primary Active Pharmaceutical Ingredient (API) in prescription and over-the-counter anti-ulcer medications.
• Formulation component for tablets and capsules used in the treatment of gastroesophageal reflux disease (GERD).
• Key raw material for the production of drugs targeting active duodenal ulcers and benign gastric ulcers.
• Research chemical in pharmacological studies for histamine H₂-receptor activity and gastrointestinal physiology.
• Reference standard in analytical laboratories for quality control and method development.
• Intermediate in the synthesis of more complex pharmaceutical compounds targeting acid secretion.

Basic Information

Item	Details
Product Name	Nizatidine
CAS No.	76963-41-2
Molecular Formula	C12H21N5O2S2
Molecular Weight	331.46 g/mol
Synonyms	N-[2-[[[2-[(Dimethylamino)methyl]-4-thiazolyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine; Axid; Nizatidinum; Tazac; Calmaxid; Gastrax; Gastraxmiz; Nizax
EINECS	Contact for details

Quality Control

Our Nizatidine is manufactured under strict quality management systems. We provide material that meets or exceeds relevant pharmacopeial standards, including USP and EP monographs. Each batch undergoes comprehensive analytical testing, including assay, impurity profiling, and residual solvent analysis. Certificates of Analysis (COA) documenting full compliance with specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to protect from moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Conforms to standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.